NITRIC OXIDE PRODUCTION & MUSCLE MAINTENANCE Protein Matabolism Muscle Maintence Nitric Oxide Production Arginine and citrulline are two amino acids that are integral to protein metabolism and utilization, as well as to the maintenance of muscle tissue. Both are key intermediates in the urea cycle, where they participate in the detoxification of ammonia via the production of urea. In addition, any arginine not converted to urea enters general circulation where it is distributed to various tissues and metabolized for other uses such as protein synthesis. Arginine serves as a precursor to nitric oxide and urea, which may support blood flow and ammonia handling during protein metabolism. Citrulline is converted to arginine in the body, supporting nitric oxide production and assisting with ammonia removal through the urea cycle. Citrulline is converted to arginine in the body, extending arginine availability for nitric oxide production. Together they participate in the urea cycle, which may aid ammonia handling during protein metabolism and muscle use.
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