Pro Supps CreaGen Creatine 101: uses science to make it the best supplement product on the market. The secret is in the HMB in the formula which is a metabolite of Leucine, the most anabolic ingredient. Creatine and Betaine work synergistically to increase bioavailable creatine, which supports cellular energy, strength and power output during resistance exercise. Obviously, we couldn’t stop there! HMB, a metabolite of the amino acid leucine enhances recovery by helping prevent muscle breakdown.